Professor of Chemistry and Biomedical Science

Director, Environmental Cancer Research Program

Senior Faculty Fellow, Barnett Institute

Editor, Journal of Chromatography

Contact Information
   Office: 312 Mugar Hall
   Voice: 617.373.4201
   Fax: 617.373.8720
   Email: r.giese@neu.edu

Education
Ph.D., MIT (Cambridge, MA)
B.S., Hamline University

Certification
Diplomate, American Board of
Clinical Chemistry

Specializations
Analytical Chemistry
Mass spectrometry

Major Research Areas
Clinical Diagnostics
DNA adducts

The research projects in Dr. Giese's laboratory combine aspects of analytical chemistry, organic chemistry and biochemistry to make advances in the reagents and techniques available for trace organic analysis. Emphasis is placed on the development of new methodology for high sensitivity and multi-analyte detection, applied especially to human samples. The principle detection techniques being used for high sensitivity are mass spectrometry and capillary electrophoresis with laser-induced fluorescence detection. Examples of analytes of interest are DNA adducts (damage to genes by carcinogens) and steriods. Potentially some of these measurements may help to individualize cancer preventions.

Selected Publications
Zhang, X., Linxiao, X., Wang, P., Wang, Z., Giese, R.W. Synthesis of Releasable Electrophore Tags for Applications in Mass Spectrometry, Bioconjugate Chemistry13, 1002-1012 (2002)

Li, G., Gao, J., Zhou, X., Shimelis, O., Giese, R.W. Handling and detection of 25 amol of near-infrared dye deoxynucleotide conjugates by capillary electrophoresis with laser-induced flourescence detection, J. Chromatogr. A, 1004, 47-50 (2003)

Shimelis, O., Zhou, X., Li, G., Giese, R.W. Phenolic extraction of DNA from mammalian tissues and conversion to deoxyribonucleoside-5?-monophosphates devoid of irbonucleotides, J. Chromatogr.A., 1053, 143-149 (2004)

Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115